[HTML][HTML] High-fat diet-induced memory impairment in triple-transgenic Alzheimer's disease (3xTgAD) mice is independent of changes in amyloid and tau pathology
EM Knight, IVA Martins, S Gümüsgöz, SM Allan… - Neurobiology of …, 2014 - Elsevier
Obesity and consumption of a high-fat diet are known to increase the risk of Alzheimer's
disease (AD). Diets high in fat also increase disease neuropathology and/or cognitive
deficits in AD mouse models. However, the effect of a high-fat diet on both the
neuropathology and memory impairments in the triple-transgenic mouse model of AD
(3xTgAD) is unknown. Therefore, groups of 2-month-old male 3xTgAD and control (non-Tg)
mice were maintained on a high-fat or control diet and memory was assessed at the age of 3 …
disease (AD). Diets high in fat also increase disease neuropathology and/or cognitive
deficits in AD mouse models. However, the effect of a high-fat diet on both the
neuropathology and memory impairments in the triple-transgenic mouse model of AD
(3xTgAD) is unknown. Therefore, groups of 2-month-old male 3xTgAD and control (non-Tg)
mice were maintained on a high-fat or control diet and memory was assessed at the age of 3 …
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